Determination of mercury in blood, urine and saliva for the biological monitoring of an exposure from amalgam fillings in a group with self-reported adverse health effects.
Identifieur interne : 000494 ( Main/Exploration ); précédent : 000493; suivant : 000495Determination of mercury in blood, urine and saliva for the biological monitoring of an exposure from amalgam fillings in a group with self-reported adverse health effects.
Auteurs : Holger Zimmer [Allemagne] ; Heidi Ludwig ; Michael Bader ; Josef Bailer ; Peter Eickholz ; Hans Jörg Staehle ; Gerhard TriebigSource :
- International journal of hygiene and environmental health [ 1438-4639 ] ; 2002.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Amalgame dentaire (composition chimique), Amalgame dentaire (effets indésirables), Appréciation des risques (MeSH), Attitude envers la santé (MeSH), Distribution tissulaire (MeSH), Exposition environnementale (MeSH), Femelle (MeSH), Humains (MeSH), Mercure (pharmacocinétique), Mercure (sang), Mercure (urine), Mâle (MeSH), Restaurations dentaires permanentes (MeSH), Salive (composition chimique).
- MESH :
- composition chimique : Amalgame dentaire, Salive.
- effets indésirables : Amalgame dentaire.
- pharmacocinétique : Mercure.
- sang : Mercure.
- urine : Mercure.
- Adulte, Appréciation des risques, Attitude envers la santé, Distribution tissulaire, Exposition environnementale, Femelle, Humains, Mâle, Restaurations dentaires permanentes.
English descriptors
- KwdEn :
- Adult (MeSH), Attitude to Health (MeSH), Dental Amalgam (adverse effects), Dental Amalgam (chemistry), Dental Restoration, Permanent (MeSH), Environmental Exposure (MeSH), Female (MeSH), Humans (MeSH), Male (MeSH), Mercury (blood), Mercury (pharmacokinetics), Mercury (urine), Risk Assessment (MeSH), Saliva (chemistry), Tissue Distribution (MeSH).
- MESH :
- chemical , adverse effects : Dental Amalgam.
- chemical , blood : Mercury.
- chemical , chemistry : Dental Amalgam.
- chemical , pharmacokinetics : Mercury.
- chemical , urine : Mercury.
- chemistry : Saliva.
- Adult, Attitude to Health, Dental Restoration, Permanent, Environmental Exposure, Female, Humans, Male, Risk Assessment, Tissue Distribution.
Abstract
It has been argued that the release of mercury from amalgam fillings is of toxicological relevance. The aim of the study was to determine the internal mercury exposure of two groups differing in their attitude towards possible health hazards by mercury from amalgam fillings. It was to be examined if the two groups differ with regard to the mercury concentration in different biological matrices and to compare the results with current reference values. Blood, urine and saliva samples were analyzed from 40 female subjects who claimed to suffer from serious health damage due to amalgam fillings ("amalgam sensitive subjects"). 43 female control subjects did not claim any association ("amalgam non-sensitive controls"). Mercury was determined by means of cold vapour atomic absorption spectrometry. Number and surfaces of amalgam fillings were determined by dentists for each subject. Median (range) mercury levels in blood were 2.35 (0.25-13.40) micrograms/l for "amalgam sensitive subjects" and 2.40 (0.25-10.50) micrograms/l for "amalgam non-sensitive controls". In urine, the median mercury concentrations were 1.55 (0.06-14.70) micrograms/l and 1.88 (0.20-8.43) micrograms/g creatinine respectively. No significant differences could be found between the two groups. Mercury levels in blood and urine of the examined subjects were within the range of background levels in the general population including persons with amalgam fillings. Stimulated saliva contained 76.4 (6.7-406.0) micrograms mercury/l in "amalgam sensitive subjects" and 57.0 (2.8-559.0) micrograms mercury/l in controls (not significant). Mercury levels in saliva did not correlate with the concentrations in blood and urine, but merely with the number of amalgam fillings or of the filling surfaces. Mercury in saliva is therefore not recommended for a biological monitoring.
DOI: 10.1078/1438-4639-00146
PubMed: 12040918
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Eickholz</name></author><author><name sortKey="Staehle, Hans Jorg" sort="Staehle, Hans Jorg" uniqKey="Staehle H" first="Hans Jörg" last="Staehle">Hans Jörg Staehle</name></author><author><name sortKey="Triebig, Gerhard" sort="Triebig, Gerhard" uniqKey="Triebig G" first="Gerhard" last="Triebig">Gerhard Triebig</name></author></analytic><series><title level="j">International journal of hygiene and environmental health</title><idno type="ISSN">1438-4639</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Attitude to Health (MeSH)</term><term>Dental Amalgam (adverse effects)</term><term>Dental Amalgam (chemistry)</term><term>Dental Restoration, Permanent (MeSH)</term><term>Environmental Exposure (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mercury (blood)</term><term>Mercury (pharmacokinetics)</term><term>Mercury (urine)</term><term>Risk Assessment (MeSH)</term><term>Saliva (chemistry)</term><term>Tissue Distribution (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Amalgame dentaire (composition chimique)</term><term>Amalgame dentaire (effets indésirables)</term><term>Appréciation des risques (MeSH)</term><term>Attitude envers la santé (MeSH)</term><term>Distribution tissulaire (MeSH)</term><term>Exposition environnementale (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Mercure (pharmacocinétique)</term><term>Mercure (sang)</term><term>Mercure (urine)</term><term>Mâle (MeSH)</term><term>Restaurations dentaires permanentes (MeSH)</term><term>Salive (composition chimique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dental Amalgam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Mercury</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Dental Amalgam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Mercury</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Mercury</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Amalgame dentaire</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Amalgame dentaire</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Mercure</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Mercure</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Mercure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Attitude to Health</term><term>Dental Restoration, Permanent</term><term>Environmental Exposure</term><term>Female</term><term>Humans</term><term>Male</term><term>Risk Assessment</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Appréciation des risques</term><term>Attitude envers la santé</term><term>Distribution tissulaire</term><term>Exposition environnementale</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Restaurations dentaires permanentes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has been argued that the release of mercury from amalgam fillings is of toxicological relevance. The aim of the study was to determine the internal mercury exposure of two groups differing in their attitude towards possible health hazards by mercury from amalgam fillings. It was to be examined if the two groups differ with regard to the mercury concentration in different biological matrices and to compare the results with current reference values. Blood, urine and saliva samples were analyzed from 40 female subjects who claimed to suffer from serious health damage due to amalgam fillings ("amalgam sensitive subjects"). 43 female control subjects did not claim any association ("amalgam non-sensitive controls"). Mercury was determined by means of cold vapour atomic absorption spectrometry. Number and surfaces of amalgam fillings were determined by dentists for each subject. Median (range) mercury levels in blood were 2.35 (0.25-13.40) micrograms/l for "amalgam sensitive subjects" and 2.40 (0.25-10.50) micrograms/l for "amalgam non-sensitive controls". In urine, the median mercury concentrations were 1.55 (0.06-14.70) micrograms/l and 1.88 (0.20-8.43) micrograms/g creatinine respectively. No significant differences could be found between the two groups. Mercury levels in blood and urine of the examined subjects were within the range of background levels in the general population including persons with amalgam fillings. Stimulated saliva contained 76.4 (6.7-406.0) micrograms mercury/l in "amalgam sensitive subjects" and 57.0 (2.8-559.0) micrograms mercury/l in controls (not significant). Mercury levels in saliva did not correlate with the concentrations in blood and urine, but merely with the number of amalgam fillings or of the filling surfaces. Mercury in saliva is therefore not recommended for a biological monitoring.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12040918</PMID><DateCompleted><Year>2002</Year><Month>11</Month><Day>19</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1438-4639</ISSN><JournalIssue CitedMedium="Print"><Volume>205</Volume><Issue>3</Issue><PubDate><Year>2002</Year><Month>Apr</Month></PubDate></JournalIssue><Title>International journal of hygiene and environmental health</Title><ISOAbbreviation>Int J Hyg Environ Health</ISOAbbreviation></Journal><ArticleTitle>Determination of mercury in blood, urine and saliva for the biological monitoring of an exposure from amalgam fillings in a group with self-reported adverse health effects.</ArticleTitle><Pagination><MedlinePgn>205-11</MedlinePgn></Pagination><Abstract><AbstractText>It has been argued that the release of mercury from amalgam fillings is of toxicological relevance. The aim of the study was to determine the internal mercury exposure of two groups differing in their attitude towards possible health hazards by mercury from amalgam fillings. It was to be examined if the two groups differ with regard to the mercury concentration in different biological matrices and to compare the results with current reference values. Blood, urine and saliva samples were analyzed from 40 female subjects who claimed to suffer from serious health damage due to amalgam fillings ("amalgam sensitive subjects"). 43 female control subjects did not claim any association ("amalgam non-sensitive controls"). Mercury was determined by means of cold vapour atomic absorption spectrometry. Number and surfaces of amalgam fillings were determined by dentists for each subject. Median (range) mercury levels in blood were 2.35 (0.25-13.40) micrograms/l for "amalgam sensitive subjects" and 2.40 (0.25-10.50) micrograms/l for "amalgam non-sensitive controls". In urine, the median mercury concentrations were 1.55 (0.06-14.70) micrograms/l and 1.88 (0.20-8.43) micrograms/g creatinine respectively. No significant differences could be found between the two groups. Mercury levels in blood and urine of the examined subjects were within the range of background levels in the general population including persons with amalgam fillings. Stimulated saliva contained 76.4 (6.7-406.0) micrograms mercury/l in "amalgam sensitive subjects" and 57.0 (2.8-559.0) micrograms mercury/l in controls (not significant). Mercury levels in saliva did not correlate with the concentrations in blood and urine, but merely with the number of amalgam fillings or of the filling surfaces. Mercury in saliva is therefore not recommended for a biological monitoring.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zimmer</LastName><ForeName>Holger</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute and Policlinic of Occupational and Social Medicine, University Hospital of Heidelberg, Heidelberg, Germany. holger_zimmer@med.uni-heidelberg.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ludwig</LastName><ForeName>Heidi</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Bader</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Bailer</LastName><ForeName>Josef</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Eickholz</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Staehle</LastName><ForeName>Hans Jörg</ForeName><Initials>HJ</Initials></Author><Author ValidYN="Y"><LastName>Triebig</LastName><ForeName>Gerhard</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Int J Hyg Environ Health</MedlineTA><NlmUniqueID>100898843</NlmUniqueID><ISSNLinking>1438-4639</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>8049-85-2</RegistryNumber><NameOfSubstance UI="D003723">Dental Amalgam</NameOfSubstance></Chemical><Chemical><RegistryNumber>FXS1BY2PGL</RegistryNumber><NameOfSubstance UI="D008628">Mercury</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Int J Hyg Environ Health. 2003 Mar;206(2):139-41; author reply 143-5</RefSource><PMID Version="1">12708236</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001294" MajorTopicYN="Y">Attitude to Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003723" MajorTopicYN="N">Dental Amalgam</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003793" MajorTopicYN="Y">Dental Restoration, Permanent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004781" MajorTopicYN="Y">Environmental Exposure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008628" MajorTopicYN="N">Mercury</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="N">Risk Assessment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>6</Month><Day>4</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>11</Month><Day>26</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>6</Month><Day>4</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12040918</ArticleId><ArticleId IdType="pii">S1438-4639(04)70146-7</ArticleId><ArticleId IdType="doi">10.1078/1438-4639-00146</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Karlsruhe</li></region><settlement><li>Heidelberg</li></settlement></list><tree><noCountry><name sortKey="Bader, Michael" sort="Bader, Michael" uniqKey="Bader M" first="Michael" last="Bader">Michael Bader</name><name sortKey="Bailer, Josef" sort="Bailer, Josef" uniqKey="Bailer J" first="Josef" last="Bailer">Josef Bailer</name><name sortKey="Eickholz, Peter" sort="Eickholz, Peter" uniqKey="Eickholz P" first="Peter" last="Eickholz">Peter Eickholz</name><name sortKey="Ludwig, Heidi" sort="Ludwig, Heidi" uniqKey="Ludwig H" first="Heidi" last="Ludwig">Heidi Ludwig</name><name sortKey="Staehle, Hans Jorg" sort="Staehle, Hans Jorg" uniqKey="Staehle H" first="Hans Jörg" last="Staehle">Hans Jörg Staehle</name><name sortKey="Triebig, Gerhard" sort="Triebig, Gerhard" uniqKey="Triebig G" first="Gerhard" last="Triebig">Gerhard Triebig</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Zimmer, Holger" sort="Zimmer, Holger" uniqKey="Zimmer H" first="Holger" last="Zimmer">Holger Zimmer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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